Latest asymmetric synthesis research method.6.Asymmetric synthesis of biological active natural product.

synthesis and characterization of potentially biological active cyclometallated organoplatinum(ii) complexes

this work is presented in five parts. in the first part preparation of the starting complex [pt(c^n)cl(dmso)], 1, in which c^n = n(1),c(2?)-chelated, deprotonated 2-phenylpyridine, and dmso = dimethylsulfoxide, and its reaction with 1 equiv of the biphosphine ligands bis(diphenylphosphino)amine, dppa, or bis(diphenylphosphino)methane, dppm, to give the complex [pt(c^n)cl(dppa)], 2, or [pt(c^n)c...

The asymmetric intramolecular Heck reaction in natural product total synthesis.

Natural Product Synthesis

The Lycopodium alkaloids are a family of structurally complex natural products, which have provoked long-term interests in their total syntheses because of their unique and fascinating architectures and potential biological activities. In particular, fawcettimine-type Lycopodium alkaloids, such as fawcettimine (1) and fawcettidine (2) (Scheme 1), have attracted broad attention from the syntheti...

Natural Product Synthesis AConcise Asymmetric Synthesis of the Marine Hepatotoxin 7-Epicylindrospermopsin**

The cyanobacterial toxin cylindrospermopsin (1) was isolated as the principal hepatotoxin from Cylindrospermopsis raciborskii in 1992 after suspicion of its involvement in an outbreak of hepatoenteritis that hospitalized 150 people on Palm Island, Australia. It has since been isolated in Japan from Umezakia natans and in Israel from Aphazinomenon ovalisporum. Following the discovery of the pare...

“ Metathesis in Natural Product Synthesis ”

Institute of Organic Chemistry, Romanian Academy, 202B Spl. Independentei, PO Box 35-108, 060023 Bucharest, Romania; E-mail: *[email protected]; **[email protected] “Metathesis in Natural Product Synthesis” subtitled ‘Strategies, Substrates and Catalysts’ benefits from a foreword by Robert H. Grubbs, joint recipient of the 2005 Nobel Prize in Chemistry for his work on the development of the...